![]() ![]() ![]() Fuhrman’s grade for kidney is based only on nuclear features. Others use only a nuclear grade (usually size, amount of chromatin, degree of irregularity, and mitotic activity). Some grading systems use only pattern, for example Gleason grading in prostate. These similarities/differences may be based on pattern (architecture), cytology, nuclear (or nucleolar) features, or a combination of these elements, depending upon the grading system that is used. Poorly differentiated and undifferentiated tumor cells are disorganized and abnormal looking they bear little (poorly differentiated) or no (undifferentiated) resemblance to the tissue from the organ of origin. Well-differentiated tumor cells closely resemble the tissue from the organ of origin. For these cancers, the grade is a measurement of how closely the tumor cells resemble the parent tissue (organ of origin). Pathologic examination determines the grade, or degree of differentiation, of the tumor. Grade, Differentiation (Codes 1, 2, 3, 4, 9) Grade unknown, not stated, or not applicable Grade codes for hematopoietic and lymphoid neoplasms Determine the Cell Indicator by applying the “Grade of Tumor Rules” within the current Hematopoietic and Lymphoid Neoplasm Manual (PDF, 1.0 MB). ![]() Determine the histology based on the current Hematopoietic and Lymphoid Neoplasm Manual (PDF, 1.0 MB).Coding Grade for Hematopoietic and Lymphoid Neoplasms Code 9 indicates cell type not determined, not stated, or not applicable. Codes 5, 6, 7, and 8 are used only for hematopoietic and lymphoid neoplasms. Hematopoietic and Lymphoid NeoplasmsĬell Indicator (Codes 5, 6, 7, 8) describes the lineage or phenotype of the cell. These are coding instructions for cases diagnosed and forward. Grade, Differentiation for solid tumors (Codes 1,2,3,4,9) and Cell Indicator for Lymphoid Neoplasms (Codes 5,6,7,8,9) Note: These instructions pertain to the data item Grade, Differentiation or Cell Indicator. 2014 Grade Rule Conversion for Prostate & Breast (PDF).Instructions for Coding Grade (PDF, 758 KB).Memo from CoC-SEER-NPCR Technical Working Group (PDF, 21 KB).For cases diagnosed 2018 and later, see the NAACCR 2018 Implementation (PDF). These grade instructions are valid for cases diagnosed through December 31, 2017. ![]()
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